Process transparency on construction sites : examples from construction companies in Brazil

Process transparency is the core concept in Visual Management (VM), which is one of the founding blocks of the Toyota Production System. This paper presents the preliminary results of a collaborative research conducted between Brazil and the UK, as part of a research effort focused on the application of Visual Management in construction. How process transparency is realized on construction sites is the main research question of the paper. The use of this concept and the implementation of the transparency theory were investigated through multiple case studies, carried out in nine different construction companies. The findings are explained through six theoretical transparency increasing approaches. The affecting parameters in the application of, the management’s perception of and several methods in process transparency in construction were identified. Further work, especially exploring the functions of process transparency on construction sites and reflecting the worker perception of the issue, is necessary to elaborate the process transparency concept

Gestao de beneficios na etapa de projecto em empreendimentos hospitalares do reino unido [Managing benefits in the design of healthcare favilities in the UK]

Proposal: The healthcare system in the United kingdomis passing through transformation and change for improvement and innovation. Within this context, healthcare facilities are being developed in a complex multi-stakeholder environment, which usually have diverse and conflicting interests and no experience in design. This contributes for difficulties in managing their requirements, leading to low quality of design. Aiming to contribute for the management of these projects, a benefits management model is being developed and introduced in the sector by the University of Salford. This model intends to support the consideration of different stakeholders’ expectations in project development. In this sense, the aim of this paper was to bring discussions about how such approach could be adopted to support the design process within those projects. This research was developed through the participation on the model implementation, in addition to a literature review on benefits management and design approaches that are used in the UK and that could support benefits management in the design process. Main findings are related to a need for anticipating the participation of designers on project development and straightening the relationship between designers and decision makers. As a result, recommendations could be done to support benefits management throughout the design process. Keywords: Design process, project management, benefits realisatio

Identification of Potential Interacting Proteins With the Extracellular Loops of the Neuronal Glycoprotein M6a by TMT/MS

Nowadays, great efforts are made to gain insight into the molecular mechanisms that underlie structural neuronal plasticity. Moreover, the identification of signaling pathways involved in the development of psychiatric disorders aids the screening of possible therapeutic targets. Genetic variations or alterations in GPM6A expression are linked to neurological disorders such as schizophrenia, depression, and Alzheimer’s disease. GPM6A encodes the neuronal surface glycoprotein M6a that promotes filopodia/spine, dendrite, and synapse formation by unknown mechanisms. A substantial body of evidence suggests that the extracellular loops of M6a command its function. However, the proteins that associate with them and that modulate neuronal plasticity have not been determined yet. To address this question, we generated a chimera protein that only contains the extracellular loops of M6a and performed a co-immunoprecipitation with rat hippocampus samples followed by TMT/MS. Here, we report 72 proteins, which are good candidates to interact with M6a’s extracellular loops and modify its function. Gene ontology (GO) analysis showed that 63% of the potential M6a’s interactor proteins belong to the category “synapse,” at both sides of the synaptic cleft, “neuron projections” (51%) and “presynapse” (49%). In this sense, we showed that endogenous M6a interacts with piccolo, synaptic vesicle protein 2B, and synapsin 1 in mature cultured hippocampal neurons. Interestingly, about 28% of the proteins left were related to the “myelin sheath” annotation, suggesting that M6a could interact with proteins at the surface of oligodendrocytes. Indeed, we demonstrated the (cis and trans) interaction between M6a and proteolipid protein (PLP) in neuroblastoma N2a cells. Finally, the 72 proteins were subjected to disease-associated genes and variants screening by DisGeNET. Apart from the diseases that have already been associated with M6a, most of the proteins are also involved in “autistic disorder,” “epilepsy,” and “seizures” increasing the spectrum of disorders in which M6a could play a role. Data are available via ProteomeXchange with identifier PXD017347.Fil: Aparicio, Gabriela Inés. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Formoso, Karina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: León, Antonella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Frasch, Alberto Carlos C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; ArgentinaFil: Scorticati, Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentin

Visual Management: Preliminary Results of a Systematic Literature Review on Core Concepts and Principles

ABSTRACT Visual management (VM) is one of the core categories of practices of Lean Production systems, providing the foundation for other improvement approaches to be implemented and, therefore, may be adopted as one of the first steps of a continuous improvement program. However, there are some challenges regarding the implementation of VM in construction sites: these are usually very large and changing environments, teams and equipment are often spread in large areas, etc. The fact that VM practices and tools are very intuitive hinders the explicit presentation on papers of concepts and principles behind this approach. Therefore, a more robust and comprehensive understanding of the term, its concepts and associated principles is necessary. Moreover, there is a gap in knowledge about the understanding of VM in construction from other knowledge areas such as visual languages, design, infrastructure, mechanics of human visual perception, among others. This paper is part of a wider research project and presents preliminary results of a systematic literature review on core concepts and principles of VM. The aim of this study is to contribute to a better understanding of VM, by collecting information from other relevant research areas

Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin

OBJECTIVE The aim of this study was to investigate whether apolipoprotein B100 of LDL suffers increased damage by glycation, oxidation, and nitration in patients with type 2 diabetes, including patients receiving metformin therapy. RESEARCH DESIGN AND METHODS For this study, 32 type 2 diabetic patients and 21 healthy control subjects were recruited; 13 diabetic patients were receiving metformin therapy (median dose: 1.50 g/day). LDL was isolated from venous plasma by ultracentrifugation, delipidated, digested, and analyzed for protein glycation, oxidation, and nitration adducts by stable isotopic dilution analysis tandem mass spectrometry. RESULTS Advanced glycation end product (AGE) content of apolipoprotein B100 of LDL from type 2 diabetic patients was higher than from healthy subjects: arginine-derived AGE, 15.8 vs. 5.3 mol% (P < 0.001); and lysine-derived AGE, 2.5 vs. 1.5 mol% (P < 0.05). Oxidative damage, mainly methionine sulfoxide residues, was also increased: 2.5 vs. 1.1 molar equivalents (P < 0.001). 3-Nitrotyrosine content was decreased: 0.04 vs. 0.12 mol% (P < 0.05). In diabetic patients receiving metformin therapy, arginine-derived AGE and methionine sulfoxide were lower than in patients not receiving metformin: 19.3 vs. 8.9 mol% (P < 0.01) and 2.9 vs. 1.9 mol% (P < 0.05), respectively; 3-nitrotyrosine content was higher: 0.10 vs. 0.03 mol% (P < 0.05). Fructosyl-lysine residue content correlated positively with fasting plasma glucose. Arginine-derived AGE residue contents were intercorrelated and also correlated positively with methionine sulfoxide. CONCLUSIONS Patients with type 2 diabetes had increased arginine-derived AGEs and oxidative damage in apolipoprotein B100 of LDL. This was lower in patients receiving metformin therapy, which may contribute to decreased oxidative damage, atherogenicity, and cardiovascular disease

Geometry and Joint Systems for Lattice-Based Reconfigurable Space Structures

We describe analytical methods for the design of the discrete elements of ultralight lattice structures. This modular, building block strategy allows for relatively simple element manufacturing, as well as relatively simple robotic assembly of low mass density structures on orbit, with potential for disassembly and reassembly into highly varying and large structures. This method also results in a structure that is easily navigable by relatively small mobile robots. The geometry of the cell can allow for high packing efficiency to minimize wasted payload volume while maximizing structural performance and constructability. We describe the effect of geometry choices on the final system mechanical properties, manufacturability of the components, and automated robotic constructability of a final system. Geometry choices considered include building block complexity, symmetry of the unit cell, and effects of vertex, edge, and face connectivity of the unit cell. Mechanical properties considered include strength scaling, modulus scaling, and structural performance of the joint, including proof load, shear load, mass, and loading area; as well as validation and verification opportunities. Manufacturability metrics include cost and time, manufacturing method (COTS versus custom), and tolerances required. Automated constructability metrics include local effects of loads imparted to the structure by the robot and assembly complexity, encompassing the ability of the robot to clamp and number of placement motions needed for assembly

Rare earth element and yttrium geochemistry applied to the genetic study of cryolite ore at the Pitinga Mine (Amazon, Brazil)

This work aims at the geochemical study of Pitinga cryolite mineralization through REE and Y analyses in disseminated and massive cryolite ore deposits, as well as in fluorite occurrences. REE signatures in fluorite and cryolite are similar to those in the Madeira albite granite. The highest &#931;REE values are found in magmatic cryolite (677 to 1345 ppm); &#931;REE is lower in massive cryolite. Average values for the different cryolite types are 10.3 ppm, 6.66 ppm and 8.38 ppm (for nucleated, caramel and white types, respectively). Disseminated fluorite displays higher &#931;REE values (1708 and 1526ppm) than fluorite in late veins(34.81ppm). Yttrium concentration is higher in disseminated fluorite and in magmatic cryolite. The evolution of several parameters (REEtotal, LREE/HREE, Y) was followed throughout successive stages of evolution in albite granites and associated mineralization. At the end of the process, late cryolite was formed with low REEtotal content. REE data indicate that the MCD was formed by, and the disseminated ore enriched by (additional formation of hydrothermal disseminated cryolite), hydrothermal fluids, residual from albite granite. The presence of tetrads is poorly defined, although nucleated, caramel and white cryolite types show evidence for tetrad effect.Este trabalho enfoca a geoquímica de elementos terras raras (ETR) e de Y no minério criolítico disseminado, no depósito criolítico maciço e na fluorita associada na mina Pitinga. As assinaturas de ETR na criolita e fluorita são similares àquelas do granito Madeira. Os maiores valores de SETR são encontrados na criolita magmática disseminada (677 a 1.345 ppm); SETR é menor na criolita maciça, com valores médios de 10,3 ppm, 6,66 ppm e 8,38 ppm, respectivamente, nos tipos de criolita nucleada, caramelo e branca. A fluorita magmática disseminada apresenta os valores mais altos de SETR (1.708 e 1.526 ppm), contrastando com a fluorita de veio tardio(34,81 ppm). A concentração de Y é maior na fluorita disseminada e na criolita magmática. As evoluções de diversos parâmetros (SETR, ETRL/ETRP, Y) podem ser seguidas através dos sucessivos estágios de evolução dos albita granitos e mineralização associada. Os dados de ETR indicam que o depósito criolítico maciço foi formado por, e o minério disseminado enriquecido por (formação adicional criolita disseminada hidrotermal), fluidos hidrotermais residuais do albita granito. A presença do efeito tetrad não é bem definida, embora as criolitas maciças nucleada, caramelo e branca apresentem algumas evidências deste efeito.FINEPAgência para o Desenvolvimento da Indústria Mineral do BrasilConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) - Departamento Nacional de Produção MineralFundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) - Programa de Apoio a Núcleos de ExcelênciaCNP

Long-Distance Transport of Finisher Pigs in the Iberian Peninsula:Effects of Season on Thermal and Enthalpy Conditions, Welfare Indicators and Meat pH

Long-distance transport in the global swine industry is more the rule than the exception. We tested the impact on the rates of temperature change and air enthalpy on the stress response and muscle pH in pigs subjected to long-distance travel from Spain to Portugal performed in the summer and winter. We found that winter journeys are more adverse for the animals because during the journey, abrupt variations in rates of temperature change and air enthalpy caused a marked physiological stress response and effects on the meat pH after 45 min. These results indicate the need to develop new environmental control strategies that mitigate abrupt temperature changes during travel to attenuate the biological cost of such long-distance transport on the animals